Two-time champion Esteghlal set to face off against Qatar’s Al Sadd in the Asia West Zone.
The Iranian giant will host Al Sadd on Aug. 27 in Tehran and play the Qatari team in return leg in Doha on Sept. 17.
Persepolis also plays Al Duhail – who has won all eight of its matches in the ACL this year – on Aug. 28 in Doha and hosts the Qatari giant on Sept. 18 in Tehran.
Kashima Antlers from Japan, who has not gone beyond the quarter-final stage, will welcome China PR’s Tianjin Quanjian.
Jeonbuk Hyundai Motors, champion in 2006 and 2016, will lock horns with fellow Korea Republic side Suwon Samsung Bluewings, who has also won the title twice – in the 2000/01 and 2001/02 seasons.