In a press briefing on Saturay, Sima-Sadat Lari said 496,253 patients have contracted the virus so far, including 3,875 new cases identified in the past 24 hours.
So far, she added, 403,950 patients have recovered from the disease or been discharged from the hospital.
Lari said 4,439 patients are also in critical conditions caused by more severe infection.
The spokeswoman noted that 4,284,413 COVID-19 tests have been taken across the country so far.
She said the high-risk “red” zones include Tehran, Qom, Mazandaran, East Azarbaijan, Isfahan, Yazd, Ardabil, Khorasan Razavi, Khuzestan, Hamadan, West Azarbaijan, Bushehr, Chaharmahal and Bakhtiari, Kohgiluyeh and Boyer-Ahmad, Alborz, Lorestan, Markazi, Ilam, South Khorasan, Kermanshah, North Khorasan, Semnan, Gilan, Zanjan, Qazvin, and Kerman provinces.
The “orange” zones also include Golestan, Hormozgan, Kurdistan, and Fars provinces, she added.