Forty-one bodies had been recovered from the wreckage, some burned beyond recognition, district police officer Israr Umrani told Reuters.
The bus carrying around 48 people crashed on the way from Balochistan’s capital of Quetta to the southern city of Karachi, officials said.
Dozens of people were combing through the wreckage, footage shared by the Edhi Foundation aid and emergency response organisation showed, and ambulance workers were carrying a dead body out of the debris.
Fatal road accidents are common in Pakistan, where traffic rules are rarely followed and roads in many rural areas are in poor condition.