The explosions come as US President Donald Trump, who has deployed a navy task force to the Caribbean, raised the possibility of ground strikes against Venezuela.
Sounds of blasts were still being heard around 2:15 am, although their exact location was unclear.
Trump on Monday said the United States hit and destroyed a docking area for alleged Venezuelan drug boats.
The Republican leader would not say if it was a military or CIA operation or where the strike occurred, noting only that it was “along the shore.”
The attack would be the first known land strike on Venezuelan soil.
President Nicolas Maduro has neither confirmed nor denied Monday’s strike, but stated Thursday he was open to cooperation with Washington after weeks of US military pressure.
The Trump administration has accused Maduro of heading a drug cartel and says it is cracking down on trafficking, but the leftist leader denies any involvement in the narcotics trade, stressing Washington is seeking to overthrow him because Venezuela has the largest known reserves of oil on Earth.
Washington has ramped up pressure on Caracas by informally closing Venezuela’s airspace, imposing more sanctions and ordering the seizure of tankers loaded with Venezuelan oil.
For weeks Trump has threatened ground strikes on drug cartels in the region, adding they would start “soon,” with Monday being the first apparent example.
US forces have also carried out numerous strikes on boats in both the Caribbean Sea and eastern Pacific Ocean since September, targeting what Washington says are drug smugglers.
The administration has provided no evidence that the targeted boats were involved in drug trafficking, however, prompting debate about the legality of these operations.
The deadly maritime campaign has killed at least 107 people in at least 30 strikes, according to information released by the US military.
Venezuela’s government has condemned what it said was a “very serious grave military aggression” by the US against multiple parts of the country after explosions were reported in the capital Caracas and other locations early on Saturday.
In a statement, the government accused the US of carrying out an attack on Caracas and the states of Miranda, Aragua and La Guaira.
President Maduro has signed a state of emergency and ordered all national defense plans to be implemented “at the appropriate time and under the appropriate circumstances,” a statement from the government read.
It also called on Venezuela’s social and political forces to mobilize and defend the country.
“The people of Venezuela and their Bolivarian National Armed Forces, in perfect popular-military-police unity, are deployed to guarantee sovereignty and peace,” a statement read.
The statement added Venezuela will also file complaints before the UN Security Council, the UN Secretary-General, and other international bodies, demanding the condemnation of the US.
