Israel is “using starvation and thirst as systematic weapons of war against civilians, in flagrant violation of international humanitarian law,” the office said in a statement.

The statement added that “the continuous closure of border crossings has caused a catastrophic deterioration in health conditions, especially among children and infants.”

The office placed full responsibility on Israel for the worsening humanitarian disaster and for “endangering the lives of hundreds of thousands of children, women and elderly people due to the lack of food, medicine and clean water.”

The statement called for the immediate and unconditional reopening of all border crossings into Gaza to allow the urgent entry of humanitarian aid, nutritional supplements and medical supplies, particularly for children and critically ill patients, “to save lives and halt the catastrophic humanitarian collapse.”

Since March 2, Israel has maintained the closure of Gaza’s main crossings, cutting off food, medical and humanitarian supplies, leading to an unprecedented deterioration of humanitarian conditions, according to reports by human rights organizations.

The Israeli army renewed its assault on Gaza on March 18, shattering a Jan. 19 ceasefire and prisoner exchange agreement.

More than 52,300 Palestinians have been killed in Gaza in a brutal Israeli onslaught since October 2023, most of them women and children.

The International Criminal Court issued arrest warrants last November for Israeli Prime Minister Benjamin Netanyahu and his former Defense Minister Yoav Gallant for war crimes and crimes against humanity in Gaza.

Israel also faces a genocide case at the International Court of Justice for its war on the enclave.

The monitor said Israeli occupation forces killed 345 Palestinians and wounded 770 others in just seven days (April 20-26).

According to Euro-Med, more than half of the Palestinians killed in the one week were children,16 percent of them were women, and 8 percent of them were elderly.

Even most of the adult males killed in Israeli attacks were working in civilian jobs or independent professions unrelated to any military or organizational activity.

The rights group stressed that in parallel to the unprecedented rise in Gaza’s civilian casualties, Israeli prime minister Benjamin Netanyahu publicly denies targeting civilians.

It called Netanyahu’s lies a blatant attempt to mislead international public opinion and cover up the crimes committed on the ground.

The human rights group stressed that this unprecedented rise in the number of civilian casualties coincides with the continued issuance of false media statements by Netanyahu, who publicly denies targeting civilians.

The monitor also condemned the international silence on the mass killings of Palestinians by Israel, calling it a moral failure and a serious breach of the legal obligations of states and the international community.

Israel launched the war of genocide in Gaza and imposed a complete siege on the strip on October 7, 2023.

Last January, the Israeli regime was forced to agree to a ceasefire deal with Hamas, given the regime’s failure to achieve any of its objectives, including the “elimination” of the Palestinian resistance movement or the release of captives.

However, Israel cut off food and medical supplies and other aid to the 2.3 million residents of the Gaza Strip on March 2, just two weeks before breaking the two-month ceasefire and prisoner-captive exchange agreement.

In total, 52,314 Palestinians have been killed and 117,792 others injured since October 7, 2023, according to the Palestinian health ministry.

Israeli forces in Gaza have violated the United Nations Genocide Convention with acts that include “causing serious bodily or mental harm to civilians” and “deliberately inflicting conditions of life calculated to bring about their physical destruction”, the human rights organisation said in its annual report released on Monday.

Israel has repeatedly “denied, obstructed and failed to allow and facilitate” humanitarian access to Gaza, and invaded the southern city of Rafah, despite warnings by the international community and the International Court of Justice about the “devastating effect it would have on the civilian population”, Amnesty noted.

Israeli air strikes have also frequently hit civilians who were following evacuation orders, while its forces continued to “arbitrarily detain and, in some cases, forcibly disappear Palestinians”, the rights group added.

“Since 7 October 2023 – when Hamas perpetrated horrific crimes against Israeli citizens and others and captured more than 250 hostages – the world has been made audience to a live-streamed genocide,” Amnesty’s secretary-general, Agnes Callamard, said in the introduction to the report.

“States watched on as if powerless, as Israel killed thousands upon thousands of Palestinians, wiping out entire multigenerational families, destroying homes, livelihoods, hospitals and schools.”

Israel and “its powerful allies, first among them the USA, claimed that or acted as if international law did not apply to them”, Callamard added.

More than 51,300 people, including at least 17,400 children, have been killed by Israeli forces in Gaza since October 7, 2023, according to Palestinian health authorities.

About 1,200 people were killed in Hamas’s October 7 attacks on Israel, according to Israeli authorities.

In its report, Amnesty also raised alarm about “unprecedented forces”, including the administration of United States President Donald Trump, that it said posed a threat to human rights globally.

“A multiplicity of assaults – against human rights accountability, against international law, and against the UN – have been but some of the hallmarks of the first 100 days of US President Donald Trump’s ‘reign’ in 2025,” Callamard contineud.

“But those reckless and punishing offensives, against efforts to end global poverty and undo long standing racial and gender-based discrimination and violence, did not start this year. Red lines don’t turn green overnight.”