According to Palestinian media reports on Monday, several people were injured in the attack on the school in Jabalia, north of Gaza City.
Several UN-run schools have been hit since Israel launched its deadly offensive on the blockaded area.
Dozens of Palestinians have been killed in Israeli attacks on UN schools in the blockaded territory.
Israel shelled Abu Hussein School in Jabalia, located 4 kilometers north of Gaza City on July 30.
According to Gaza’s Health Ministry officials, at least 17 Palestinians were killed by Israeli shelling against the UN-run school.
Scores of people also suffered injuries in the deadly attack on the UN-run school.
On July 24, Israeli tank shells slammed into a school in Beit Hanoun in the northern Gaza Strip. Sixteen people were killed and hundreds of people were also wounded in the attack.
More than 2,130 Palestinians, including around 570 children, have been killed since Israel launched its onslaught on Gaza on July 8. Some 11,000 others have been wounded.
The United Nations says over 80 percent of the killed Palestinians have been civilians.
Nearly 400,000 Palestinian children are in immediate need of psychological help due to “catastrophic and tragic impact” of the Israeli war, according to the United Nations Children’s Fund (UNICEF).
Tel Aviv says 68 Israelis have been killed in the conflict so far, but Hamas puts the number at more than 150.
The Ezzedine al-Qassam Brigades, the military wing of the Palestinian resistance movement Hamas, has been launching retaliatory attacks against Israel.