Al-Sharaa will be accompanied by Foreign Minister Asaad Hassan al-Shaibani and a high-level diplomatic delegation, according to the Syrian Arab News Agency (SANA).
The occasion marks the first participation by a Syrian president since 1967 and its first ever participation in the High-Level Week.
Al-Sharaa and al-Shaibani will take part in numerous meetings and events, in addition to holding bilateral meetings with leaders of states and heads of delegations participating in the UN General Assembly.