In a telephone conversation with the governor-general of Khorasan Razavi on Wednesday, President Rouhani was briefed on the latest information about rescue efforts in the disaster-hit region.
He also ordered Khorasan Razavi to ask for help from neighboring provinces if necessary.
On Wednesday morning, a tremor struck some 100 kilometers (62 miles) southeast of Mashhad, the capital of Khorasan Razavi, prompting rescue and rapid response teams to be dispatched to the affected areas.
According to the Iranian Seismological Center of Tehran University, the epicenter of the earthquake was determined at Sefid Sang, a city in Qalandarabad District in the province.
The epicenter, with a depth of 10 km, was determined to be at 35.83 degrees of latitude and 60.26 degrees of longitude.
Reports suggest two people have died and a dozen others have been injured in Sefid Sang.
Several aftershocks have been felt in Mashhad as well as many nearby cities and villages.