IFP Exclusive

Iranian Researchers Treat Liver Lesions Using Stem Cells

A group of Iranian scientists at the Royan Research Institute and Iran University of Medical Sciences have designed a method that uses stem cells to treat liver diseases.

Mesenchymal stem cells produce secretory vesicles and release them to their environment. Studies have shown that these vesicles have therapeutic effects on other cells.

Due to the tendency of the liver cells to absorb these secretory vesicles, they are widely used to treat liver diseases or to transfer drugs to the liver.

However, rapid destruction of these vesicles in the extracellular environment reduces their effect on the liver.

To overcome this problem, Iranian researchers at Royan Research Institute and Iran University of Medical Sciences designed a method in which polyethylene glycol was combined with the secretory vesicles of mesenchymal cells so that the vesicles were encapsulated in polyethylene glycol.

Thus, with the gradual degradation of the encapsulated polymer, the vesicles were released gradually over a month.

Four weeks after injection of the vesicles to the animal suffering from liver fibrosis, the liver of the animal was removed and examined through laboratory methods.

The results of the study, published in the international journal “ACS Applied Materials & Interfaces” showed that the use of polymer-encapsulated secretory vesicles improves the hepatic status of the animal compared to the conventional method.

Using this new method improved the anti-fibrotic, anti-inflammatory, anti-apoptotic, and liver regeneration effect by secretory vesicles of mesenchymal stem cells by 40 to 50%.

The results showed that MSCs could be used as an effective treatment for liver lesions.

Also, the use of encapsulation of these vesicles in the polymer has been introduced as a method to effectively use them in therapeutic processes.

IFP Editorial Staff

The IFP Editorial Staff is composed of dozens of skilled journalists, news-writers, and analysts whose works are edited and published by experienced editors specialized in Iran News. The editor of each IFP Service is responsible for the report published by the Iran Front Page (IFP) news website, and can be contacted through the ways mentioned in the "IFP Editorial Staff" section.

Recent Posts

Iran says ready for both cooperation and confrontation

The spokesperson for the Atomic Energy Organization of Iran, Behrouz Kamalvandi, has said while Iran…

7 hours ago

Iranian MP calls for Tehran to leave NPT

A senior Iranian MP has called for Iran to leave the NPT amid tension between…

12 hours ago

Russian president announces mass production of Oreshnik missiles

Russian President Vladimir Putin has confirmed the decision to begin serial production of the new…

12 hours ago

China-Iran relations strengthen amid global changes: Chinese ambassador

Chinese Ambassador to Iran, Cong Peiwu, has reaffirmed China's unwavering commitment to strengthening friendly cooperation…

13 hours ago

At least six Israeli soldiers commit suicide, thousands more get mental health treatment amid war: Report

At least six Israeli soldiers have taken their own lives in recent months, the Israeli…

15 hours ago

Britain suggests would comply with ICC warrant and arrest Israeli PM

The British government has announced it will comply with its obligations under domestic and international…

16 hours ago